INS and hyperinsulinism: Both groups of fat‐fed mice exhibited fasting hyperglycemia (40% increase), fasting hyperinsulinemia (55% increase), delayed glucose homeostasis kinetics (35%–80% increased AUC), and glucose‐stimulated insulin levels (40% increase) versus normal chow controls when administered intraperitoneal glucose (all p < 0.001; Figure S1C–G).