The PPI and KEGG enrichment pathway analyses demonstrated that clozapine induces agranulocytosis by modulating the hematopoietic cell lineage and JAK–STAT signaling pathways via interleukin‐3 (IL3), IL6, IL2 receptor subunit alpha (IL2RA), and granulocyte colony‐stimulating factor. This evidence concerns the gene SOAT1 and Absence of circulating granulocytes.