NPPB and hydrops fetalis: They report a 24% greater reduction in NT-proBNP with Sac/Val vs. control (ROC 0.76; 95% CI 0.69–0.83; P < 0.0001), and a 30% reduction in CV death or hospitalisation for HF with Sac/Val vs. control (HR 0.70; 95% CI 0.54–0.91; P = 0.0077).