Family history of cancer, age at diagnosis, TNBC and > 1 primary BC on their own were associated with a similar prevalence of P/LP variants in BRCA1/2. However, as has been demonstrated in other studies, participants with two or three indications were significantly more likely to have a P/LP variant in BRCA1/2 detected [37, 38, 40]. The gene discussed is BRCA1; the disease is cancer.