Systemic symptoms such as anorexia and fatigue, the summation of overall symptomatic distress, interference with normal activity and global QoL, and the total LCSS score all showed a correlation with blood neutrophil‐to‐lymphocyte ratio (NLR), C‐reactive proteins (CRP) and vascular endothelial growth factor (VEGF) levels (spearman correlation >0.25, p < 0.05). This evidence concerns the gene VEGFA and Anorexia.