By contrast, the WNT/β-catenin target gene and WNT signaling potentiator Lgr5, Wnt11, and the context-dependent WNT modulator Sfrp2 were upregulated in the Wnt1-Cre;Fgfr2−/− AF (Fig. 7C). This evidence concerns the gene LGR5 and atrial fibrillation.