By comparing differentially expressed genes identified in the RNA-seq analysis with the cluster-enriched genes from the scRNA-seq dataset, we found that 40 of 42 AF1-enriched genes, 19 of 25 AF2-enriched genes, and 46 of 48 EM-enriched genes identified were upregulated in the Wnt1-Cre;Fgfr2−/− AF (Fig. S5). The gene discussed is WNT1; the disease is atrial fibrillation.