FGFR2 and craniosynostosis: For example, syndromes associated with genetic variants in fibroblast growth factor receptor 2 (FGFR2), including Apert, Pfeiffer, Crouzon, and bent bone dysplasia, often present with multi-suture craniosynostosis, as well as a persistently open anterior fontanelle (AF) (Azoury et al., 2017; Merrill et al., 2012; Reardon et al., 1994; Wilkie et al., 1995).