COX8A and complement factor I deficiency: For all factors tested, two-way ANOVA found a significant effect of factor deficiency (factor VIII: F2,12=11.54, p = 0.002; factor IX: F2,12=17.27, p = 0.0003; factor XI: F2,12=20.10, p = 0.0001; factor XII: F2,12=28.68, p < 0.0001).