In this study, we analyzed a dataset of acute myocardial infarction and determined that 1 week after myocardial infarction was the time point at which the differential gene was most pronounced in the mouse cardiac, and found that there was a crosstalk between mitochondrial autophagy and myocardial infarction, and the discovery of genes Aco2, Atp5a1, Ndufs3 and Ndufv1 provides a potential molecular target for a possible link between myocardial infarction and mitochondrial metabolism. This evidence concerns the gene ACO2 and myocardial infarction.