NLRP3 and cardiomyopathy: Additionally, it has been studied in mitochondria, and down-regulation of Atp5a1 by the use of small interfering RNAs impairs mitochondrial function and induces activation of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome, which has been demonstrated in the pathogenesis of cardiomyopathy [54].