We report two probands, ES-4 and ES-10, with two novel denovo mutations, a missense variant NM_015100.4: c.776 C>T (p. Pro259Leu) in exons 19 of POGZ and non-frameshift variant NM_003403.5: c.141_143delGGA (p. Glu47del) in exon 1 of YY1 genes causing White Sutton syndrome and Gabriele-de Vries syndrome Respectively. The gene discussed is POGZ; the disease is white-sutton syndrome.