In a recent report of YY1 gene truncating mutation, depicted phenotypic milestones of learning disability, autoimmune disorder, facial dysmorphism, delayed neuromotor development, indicating that YY1 defects are variable in multiple cases, majorly these changes were discovered in zinc fingers domain that binds DNA also called repression domain, a few protein truncations but no missense mutation in the N-terminal domain [48]. The gene discussed is YY1; the disease is learning disability.