In CIS-induced depression mice (stressed, STR, Fig. 1a), CORT and ROS/RNS were increased in the plasma (Fig. 1b and c; t = 2.773, df = 11, P = 0.0181 and t = 3.163, df = 11, P = 0.009). The gene discussed is CORT; the disease is depressive symptom measurement.