According to Yao et al., activation of the NLRP3 inflammasome can increase IKur and IKAch production, which are inward rectifying potassium currents, and can shorten action potential duration (APD), decrease effective refractory period (ERP), and facilitate reentry, eventually increasing the incidence of atrial fibrillation [34]. The gene discussed is NLRP3; the disease is atrial fibrillation.