NOS3 and hypertensive disorder: It also induces hypertension by lowering endothelial nitric oxide (eNOS) levels, promoting the dissociation of eNOS via AngII/Ca2 + /calmodulin-dependent protein kinase II (CaMKII)-α, and increasing the imbalance between vascular reactive oxygen species (ROS) and nitric oxide (NO) [171, 172].