Two studies evaluated the effect of colchicine in GA, and the combination of colchicine treatment showed no significant improvement in uric acid [20, 25], but could upregulate expression of miR-223-3p and miR-451a, downregulated COX-2 and IL-1β [20] and treated with colchicine had fewer acute gout flares [25]. The gene discussed is PTGS2; the disease is gout.