In a hyperglycemic state, the release of inflammatory factors such as IL-6, TNF-α, IL-8, and IL-1β can activate hepatic stellate cells and Kupffer cells, causing liver fibrosis [32], and can also stimulate cardiac fibroblasts, exacerbating myocardial fibrosis [33]. This evidence concerns the gene CXCL8 and Hepatic fibrosis.