RHO and retinal degeneration: Our present study focused on the effect of Rabin8 mutants on rhodopsin trafficking and defined, at the molecular level, the Rab11-dual effector pathway and Rabin8 in particular as a main target of the RIS NDR2 kinase, the malfunction of which can undoubtedly contribute to the outcome of (erd) gene mutation leading to retinal degeneration and early-onset blindness.