PNPLA3 and diabetes mellitus: Another study used an Italian cohort of 546 patients with either histologic MASLD or vibration-controlled transient elastography >11–11.5 kPa and at least 1 metabolic syndrome criterion and developed a combined genetic and metabolic staging system, including PNPLA3, TM6SF2, and HSD17B13 genotypes along with age, sex, thrombocytopenia, diabetes, hypoalbuminemia, and low HDL concentration.106