PNPLA3 and metabolic dysfunction-associated steatotic liver disease: The strongest common MASLD-promoting variant identified to date, PNPLA3-rs738409-G corresponding to I148M, was initially thought to potentially be a loss-of-function variant; however, landmark knockout mouse studies established that this was not the case, as the Pnpla3-knockout mouse did not develop MASLD/MASH.75