They generated polygenic risk scores, including variants in PNPLA3, TM6SF2, MBOAT7, HSD17B13, and APOE that were associated with the incidence of HCC, even after adjustment for age-male--albumin-bilirubin-platelets score and an internally derived risk score for HCC.116. This evidence concerns the gene TM6SF2 and hepatocellular carcinoma.