,79,80 Similar findings, further enforcing the importance of lipid export in protection from MASLD, have been seen with APOE variants that predispose to liver disease but may be protective against Alzheimer’s disease48 and an MLXIPL variant that associates with reduced serum triglycerides but has a higher risk of MASLD.81 Here, MLXIPL is linked to metabolic dysfunction-associated steatotic liver disease.