STING1 and COVID-19: Above all, TNF-α combines with TNFR and strengthens the NF-κB pathway,404 whereas IL-6 enhances the JAK/STAT pathway, increasing the proinflammatory factors independently.405,406 Moreover, the cGAS-STING pathway activated by released mtDNA facilitates the expression of type I IFN genes in COVID-19.407 Conversely, 3CL, ORF3a, ORF9b, and ORF10 of SARS-CoV-2 directly connect with STING and suppress the IFN response.392,408,409