Given that ACE2 is widely expressed in most epithelial cells, SARS-CoV-2 can successfully infect various organs.16,17 According to previous studies, the S protein is necessary for SARS-CoV-2 invasion of the host cells,18 and the toxicity and infectivity of different variants and subvariants chiefly depend on the mutations in the gene encoding the S protein.19,20 Amino acid replacement and changes in the S protein structure affect SARS-CoV-2 invasive ability, incurring the loss of efficacy of the original antibodies;21,22 thus, superinfection is a concern in COVID-19. This evidence concerns the gene PROS1 and COVID-19.