APOE and Alzheimer disease: Table 2 presents the results of the reduced model, which best describes the model variance. AD status predicted the strongest reduction in brain metabolism [β = 1.04, 95% CI 0.92–1.15, p<0.001], followed by age [β = 0.01, 95% CI 0.01–0.02, p<0.001] and APOE4 carrier status [β = 0.32, 0.25–0.38, p<0.001]. Higher variable relevance is indicated by higher values of %INCMSE and INCNodepurity (Table 2 in S1 File).