Western blot analysis showed that XAV-939 suppressed the elevation of phosphorylated LRP6 (p-LRP6), total β-catenin, and nuclear β-catenin, and decreased the levels of p–β-catenin levels in ICC TICs, with no change in LRP6 expression (Supplemental Figure 3J), indicating effective inhibition of WNT/β-catenin signaling. Here, LRP6 is linked to intrahepatic cholangiocarcinoma.