While haploinsufficiency mice models for Setd1a and Grin2a have been explored within schizophrenia pathophysiology (Chen et al, 2022; Farsi et al, 2023; Mukai et al, 2019; Nagahama et al, 2020), further investigation into these genes’ cellular and molecular pathology is crucial for understanding the pathology of schizophrenia in light of the disease’s heterogeneous nature and shared pathologies among affected individuals. The gene discussed is SETD1A; the disease is schizophrenia.