Compared with wild-type mice, deletion of CD36 causes a decrease in the level of ROS in the liver, with decreased expression of histone deacetylase 2 and elevated activation of acetyl histone 3, which binds to the monocyte chemotactic protein-1 promoter, leading to the activation of monocyte chemotactic protein-1 transcription and promoting NASH.27 The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatohepatitis.