Specifically, CD36 anchors Notch1 in lipid rafts and blocks the Notch1/γ-secretase interaction, inhibiting γ-secretase–mediated production of N1ICD in hepatocytes and thus exerting a protective effect against NASH diet–induced liver injury and fibrosis.58 This evidence concerns the gene NOTCH1 and metabolic dysfunction-associated steatohepatitis.