Multiple clinical studies have shown increased expression of CD36 in the liver of patients with chronic hepatitis C.13,67 Cheng et al68 proved that the stages of HCV attachment and entry into host cells are associated with CD36, a mechanism linked to the interaction of CD36 and HCV E1 proteins and blocking CD36 in vitro could significantly reduce HCV replication. This evidence concerns the gene CD36 and chronic hepatitis C virus infection.