CD36 and obesity due to melanocortin 4 receptor deficiency: Zhou et al23 and Zeng et al24 reported that obesity-induced upregulation of the nuclear orphan receptor NR2F6, as well as INSIG2-dependent SREBP1 and the transcription factors ATF4 and SOX2, promotes CD36 expression in liver tissues, leading to enhanced fatty acid uptake and the development of NAFLD.