Since SARP-3 did not have a sufficient serum biobank of healthy controls, we leveraged the database from the Rutgers Corona Cohort (RCC) study (6) and obtained 273 serum samples of the study participants without a known history of asthma or other lung diseases, shown in Supplemental Table 1 (see detailed inclusion and exclusion criteria in Supplemental Methods). The gene discussed is SFRP5; the disease is asthma.