TP53 and cancer: Although “cell cycle” and “glycolysis” often ranked at the top, changes in PDAC cuts across other pathways, including “focal adhesion,” “p53,” “ECM-receptor alterations,” and “pathway in cancer.” However, the high expression of glycolysis and cell cycle/division pathways was so consistent that it seems plausible that these changes are central to the origin or progression of PDAC.