Importantly, a concentration of 10 ug/ml rEndocan was able to completely displace rPDGFββ from GBM cells, while rPDGF-BB at the corresponding concentration was able to displace only half of the rEndocan molecules (Fig. 4b), suggesting that Endocan can interact with other receptors in addition to PDGFRA. The gene discussed is ESM1; the disease is glioblastoma.