Also, the infiltration of CD8+ and CD8+PD-1+ T cells was significantly higher in tumors grown in NAC1-KO mice than in tumors grown in WT animals (Figure 1G), suggesting that exhaustion and reduced survival of CD8+ T cells may contribute to the enhanced functional fitness of the tumor-infiltrating Tregs in NAC1-KO mice. This evidence concerns the gene CD8A and neoplasm.