Because FoxP3+ Tregs are critically involved in tumor development and progression via suppressing antitumor immunity and the elevated number of FoxP3+ Tregs in the TME is positively correlated with poor prognosis in patients with cancer (12), we intended to know whether and how NAC1-mediated control of Tregs and their function affect tumorigenesis. Here, FOXP3 is linked to neoplasm.