This splicing-centric mechanism received further support with the demonstration that Rbm20 KO mice phenocopy KO rats with DCM and proarrhythmic changes expected to underlie the propensity for arrhythmias in individuals carrying pathogenic RBM20 genetic variants (van den Hoogenhof et al. 2018). Here, RBM20 is linked to familial dilated cardiomyopathy.