NALCN and neurodegeneration with brain iron accumulation 2A: Mutations in NALCN are associated with neuromuscular disorders including severe hypotonia, infantile neuroaxonal dystrophy (INAD), congenital contractures, cognitive delay, autism, epilepsy, bipolar disorder, and cardiac/respiratory problems (Aoyagi et al., 2015; Cochet-Bissuel et al., 2014; Gal et al., 2016).