ATG5 and infection: These and other activities of ATG5 underly the unique and often perplexing phenotypic manifestations of ATG5 observed in cells and in murine infection models (Wang et al., 2023; Castillo et al., 2012; Virgin and Levine, 2009; Watson et al., 2012; Kimmey et al., 2015; Golovkine et al., 2023; Kinsella et al., 2023), which served as the initial impetus for the present study.