Inactivation of Atg5 in myeloid lineage renders mice excessively susceptible to acute infection with M. tuberculosis attributed to excessive inflammation (Wang et al., 2023; Castillo et al., 2012; Watson et al., 2012; Kimmey et al., 2015; Golovkine et al., 2023; Kinsella et al., 2023), which did not extend to other phases of infection as tested here in a murine model of latent tuberculosis (Mccune and Tompsett, 1956; Mccune et al., 1956; Scanga et al., 1999, Figure 1—figure supplement 1A–D). Here, ATG5 is linked to infection.