PPIG and major depressive disorder: Fluoxetine is the only licensed medication for CYP (ages 8+) for moderate to severe depression in the UK based on its efficacy and relative safety (Goodyer et al., 2007, 2008; Hetrick, Merry, McKenzie, Sindahl, & Proctor, 2007; March et al., 2004; Thapar et al., 2022).