Early in the COVID-19 pandemic, Gordon et al. expressed tagged SARS-CoV-2 proteins in human embryonic kidney cells (HEK293T/17) and employed affinity purification mass spectrometry (AP-MS) to map proteome-wide virus-host protein interactions, in which a putative interaction between catalytically inactive SARS-CoV-2 Mpro (Cys145Ala) and the human tRNA methyltransferase TRMT1 was identified (Gordon et al., 2020b). The gene discussed is TRMT1; the disease is COVID-19.