Nestin-Fgf13 cKO male mice suffered spontaneous seizures in their home cage (Video 1) as early as P12, followed by premature death (Figure 1D), consistent with mouse models of DEE that exhibit SUDEP (Bunton-Stasyshyn et al., 2019; Han et al., 2020). Here, NES is linked to developmental and epileptic encephalopathy.