IL2RA and major depressive disorder: Treatment with SSRI was associated with lowered PTSD, depression, and IL-1β levels and increased IL-2R for all groups relative to levels of comparison participants.16 Women who were sexually assaulted were followed-up at six months and one year; while there were no baseline differences in IL-1β or cortisol compared to controls, after treatment with interpersonal psychotherapy or SSRI, victims’ IL-1β and cortisol were higher than in comparison participants despite improvement in depression and PTSD symptoms.