Reduced peak INa due to Scn5a loss-of-function mutation can cause a series of arrhythmias such as atrial fibrillation, Brugada syndrome, long QT syndrome, sudden cardiac death, and ventricular tachycardia etc (Han et al., 2018; Savio-Galimberti et al., 2018). The gene discussed is SCN5A; the disease is Brugada syndrome.