SCN5A and Arrhythmia: Reduced peak INa due to Scn5a loss-of-function mutation can cause a series of arrhythmias such as atrial fibrillation, Brugada syndrome, long QT syndrome, sudden cardiac death, and ventricular tachycardia etc (Han et al., 2018; Savio-Galimberti et al., 2018).