CYP2B6 and congenital adrenal hyperplasia: In 1977, Koizumi et al. reported that adrenal mitochondria from a patient with lipoid CAH had normal P450-mediated 11β-hydroxylase and 18-hydroxylase activities but could not convert cholesterol to pregnenolone; this suggested that the lipoid CAH mitochondria lacked the mitochondrial cholesterol side-chain cleavage enzyme, P450scc (Koizumi et al. 1977).