CYP11A1 and congenital adrenal hyperplasia: Taken together, these reports were regarded as showing that lipoid CAH was a defect in the enzymatic conversion of cholesterol to pregnenolone; hence, the disorder was clinically termed ‘20,22 desmolase deficiency’, i.e., a defect in P450scc; by 1985, 32 cases of lipoid CAH had been reported (Hauffa et al. 1985).