WNK2 and cancer: Furthermore, KEGG and Reactome pathway analyses revealed that the significantly enriched pathways in the high CDI group were apoptosis, the Wnt signaling pathway, pathways in cancer, the mitogen-activated protein kinase (MAPK) signaling pathway, and extracellular matrix organization, suggesting that the differential expression of these DEGs may be associated with changes in the tumor immune microenvironment (Fig. 6E and F).