CD8A and neoplasm: By ST we demonstrated that KPC06 tumor bearing mice treated with L19-IL2 alone, or especially when combined with FOLFOX, significantly enhanced immune activation and cytotoxicity, evidenced by upregulation of key immune-related genes and increased infiltration of CD8a+ T-lymphocytes and NK cells into the tumors, while FOLFOX alone mainly boosted cytotoxicity genes.