NFKB1 and colorectal carcinoma: The NF-κB signaling pathway is a cellular cascade mechanism whereby upstream signals heighten target gene expression in a p65-dependent way, consequently impacting cell proliferation and inflammatory responses.56 Our study demonstrated that the NOD1 receptor is crucial for the L. intestinalis signal sensor and consequent molecular events leading to upregulation of CCL5 selection of CRC cells.