Moreover, it has been reported that deletion of caspase 1 prevented chronic stress-induced cognitive impairment and depressive-like behaviors, but corticosterone changes were not reported.36,37 Caspase 1 and caspase 11 are key molecules modulating canonical and noncanonical inflammatory signaling.38 These studies combined with our data reported here suggest that inflammation acts as the downstream effector of corticosterone and plays a key role in the pathogenesis of chronic stress-induced brain disorders. This evidence concerns the gene CASP1 and Cognitive impairment.