According to research, phospholipids, Angiopoietin-like 3 protein (ANGPTL3), lecithin cholesterol acyltransferase (LCAT), and the protein encoded by the OCT-1 gene are involved in the pathophysiology of atherosclerosis by promoting LDL infiltration, CD40 acceleration, HDL concentration reduction, and different atherosclerosis-leading processes into the vascular wall and promoting endothelial lesion. This evidence concerns the gene CD40 and atherosclerosis.