CD4 and infection: Since C. trachomatis is an intracellular pathogen, if cDC1s are more effective than cDC2s in activating C. trachomatis-specific CD8+ T cells, a differential response between the two DC subsets upon infection—either in terms of survival or expression of co-inhibitory and co-stimulatory molecules—may contribute to the lack of an effective CD8+ T cell response generated against C. trachomatis compared to CD4+ T cells.