Tgfβ1 was previously shown to stabilize Hif1a in cancer cell lines through down-regulation of PHD2 in a Smad-dependent manner, but here we show that in primary chondrocytes, knockdown of Smad2 had no effect on the Tgfβ2-induced glycolysis or Glut1 expression (28). The gene discussed is TGFB1; the disease is cancer.