To gain a better understanding of the regulation of ferroptosis during HCMV infection, we studied the modulation of lipid peroxidation during infection by investigating two enzymes responsible for controlling lipid peroxidation: GPX4 and ferroptosis suppressor protein 1 (FSP1, also known as apoptosis-inducing mitochondria-associated 2). This evidence concerns the gene AIFM2 and infection.