TTN and familial dilated cardiomyopathy: Some of the most common genetic triggers of DCM are mutations in genes (e.g., TTN, LMNA, MYH7, TNNT2, and MYBPC3) encoding cytoskeletal, sarcomeric, and nuclear envelope proteins such as titin, lamin A/C, myosin heavy chain 7, troponin T2, and myosin binding protein C3 in human cardiomyocytes (2–4).