Thus, it is conceivable that dysregulation of Gi/o signaling due to the absence of RGS2, RGS5, or both RGS proteins could also lead to the loss of homeostatic negative regulation or profibrotic CREB activation, predisposing to the disinhibition of sympathetic-mediated myocardial fibrosis in DCM. Here, PITX2 is linked to familial dilated cardiomyopathy.