Mutations in the actin-binding protein, filamin C, and RNA-binding motif protein 20 (RBM20) have been identified in 1%–5% of all DCM cases with a severe phenotype and often associated with ventricular arrhythmias and sudden cardiac death (5, 55, 59, 62, 63). This evidence concerns the gene RBM20 and Ventricular arrhythmia.