RGS2 and cardiac hypertrophy: Isoproterenol-induced hypertrophy in rat neonatal ventricular cardiomyocytes, via the activation of β-adrenergic receptor (βAR)-Gαs signaling, was accompanied by upregulation of RGS2 mRNA, and RGS2 has been found to have GAP-independent activity in modulating cardiac hypertrophy in this pathway (48).