Mutations in LMNA that lead to DCM include the H222P mutation, which was shown to cause increased ERK1/2 phosphorylation (pERK1/2) in mice, and activation of ERK1/2 was, in turn, found to mediate cofilin-1 phosphorylation (53). The gene discussed is LMNA; the disease is familial dilated cardiomyopathy.