However, most researchers agree that, in addition to traditional risk factors such as age, smoking, blood pressure, and body mass index, HIV-related factors—including chronic inflammation, CD4+T-cell counts <200 cells/mm3, nadir CD4+T-cell counts <200 cells/mm3, and metabolic disorders associated with ART, such as dyslipidemia and insulin resistance—may also contribute to accelerated arterial stiffening [17,18,19,20]. The gene discussed is CD4; the disease is metabolic disease.