Secondly, constitutive hnRNP K downregulation via the generation of C8-D1A shHnRNPK clones with diminished hnRNP K expression similarly demonstrated increased E2 glycoprotein synthesis upon CHIKV 181/25 and ΔhnRNPK-BS1 infection (Figure 5E–G), which similarly contrasts with the transcriptional profiles observed within the same cell clones (Figure 4M,N). This evidence concerns the gene HNRNPK and infection.