SREBF2 and viral infectious disease: It has been suggested that SREBP2 mechanistically affects viruses through the remodeling of the lipidome (including membranes) and cholesterol biosynthesis [51]; accordingly, cholesterol has been identified as an important entry factor for SARS-CoV-2 while SREBP2 (along with SREBP1 and 1c) has been identified to promote viral infection in MERS-CoV [52].