Though we did not observe significant methylation changes at the IL-2 promoter in PBMC CD8+ T cells post-SIV infection compared to pre-infection (Figure 2B and found lower methylation in intestinal CD8+ T cells compared to lymph nodes in both SIV-naïve and infected animals (Figure 3B), it remains possible that the promoter region critical for IL-2 transcriptional control during SIV infection may be different in infant rhesus macaques from the one assessed in our study, which was based on the results of previous human and murine studies. The gene discussed is CD8A; the disease is infection.