The reduction in methylation at all 3 CpG sites post-SIV-infection compared to pre-infection in PBMC CD8+ T cells (Figure 4A) and the hypomethylation of site −410 in SIV-infected animals exclusively in intestinal compared to lymph node CD8+ T cells (Figure 6B) suggest that these alterations are induced by SIV infection. This evidence concerns the gene CD8A and infection.