Overall, our cytokine-specific data suggest that in CD8+ T cells from chronic SIVmac239/251 infection of infant rhesus macaques, IFNγ and IL-2 promoters are poised for active transcription with lower methylation levels, which contrasts with the expectation from functionally dysregulated CD8+ T cells associated with chronic SIV infection. Here, IL2 is linked to infection.