At the TNFα promoter, we observed a trend towards increased promoter-wide methylation in PBMC CD8+ T cells post-SIV infection compared to pre-infection (Figure 2C) and a trend towards higher methylation in both intestinal and lymph node CD8+ T cells in SIV-infected compared to uninfected animals (Figure 3C), suggestive of gene repression during chronic SIV infection. This evidence concerns the gene CD8A and infection.