The higher permissiveness of the IFNγ promoter for active gene expression inferred by the hypomethylation observed in PBMC CD8+ T cells post-SIV infection compared to pre-infection (Figure 2A) and intestinal compared to lymph node CD8+ T cells in SIV-infected animals (Figure 3A) likely represents one of the mechanisms underlying the higher IFNγ mRNA [49] and cytokine levels in plasma that have been described during HIV-1 infection [50,51]. Here, IFNG is linked to infection.