CD8A and infection: CpG site −702, a predicted Foxp3 binding site, showed reduced methylation in all animals post-infection versus pre-infection in PBMC-CD8+ T cells (Figure 4D), while CpG site −644, a predicted C/EBPβ binding site, was hypomethylated in intestinal CD8+ T cells in SIV-infected animals compared to SIV-uninfected animals (Figure 4F).