The demethylation of CpG site −702 post-SIV-infection versus pre-infection at the IL-2 promoter in PBMC—CD8+ T cells was in contrast with a previous report where none of the IL-2 promoter CpG sites were differentially methylated in PBMC- CD8+ T cells in HIV-1 non-controllers compared to controllers and uninfected individuals [55]. The gene discussed is IL2; the disease is infection.