More studies, however, have increasingly highlighted the role of RT in modulating both local and systemic immune responses to exert anti-tumor immune effects, including the promotion of antigen recognition of tumor-specific CD8+ T cells to attack both irradiated and non-irradiated tumors [6,7].Furthermore, the immunostimulatory impact of radiation is influenced by variable factors such as radiation doses and fractionation regimens [8,9]. Here, CD8A is linked to neoplasm.