CD79A and infection: Theoretically, this should be possible because HIV-1 infection generates serum IgA antibodies that inhibit the in vitro infection of target cells by not only “easy to neutralize” tier 1 HIV-1 isolates [11,12] but also by “moderately difficult to neutralize” tier 2 strains [13,14], which better represent global circulating HIV-1 isolates [15].