Under certain pathological conditions, they may also secrete antibodies to self-antigens and cause autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and Neuromyelitis Optica (NMO). Here, MOG is linked to systemic lupus erythematosus.