Under these conditions, they express CXCR5; enter B cell follicles; present self-antigens to FDC and TFH; initiate GC reactions against self-antigens and contribute to autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS) and rheumatoid arthritis (RA) [60]. The gene discussed is CXCR5; the disease is rheumatoid arthritis.