Under certain pathological conditions, they may also secrete antibodies to self-antigens and cause autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and Neuromyelitis Optica (NMO). This evidence concerns the gene OMG and systemic lupus erythematosus.